THE ENZYMATIC SYNTHESIS OF FATTY ACIDS BY ALDOL CONDENSATION
Open Access
- 15 October 1958
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 44 (10), 993-998
- https://doi.org/10.1073/pnas.44.10.993
Abstract
The synthesis of fatty acids was studied in enzyme systems obtained from pigeon liver tissue. Experimental evidence is presented to show that the formation of long-chain derivatives of coenzyme A occurs from acetaldehyde and malonyl coenzyme A in the presence of reduced triphosphopyridine nucleotide and Mn++ ions. Adenosine triphosphate is not required for the reaction. A mechanism for the synthesis of fatty acids is proposed on the basis of these findings.This publication has 13 references indexed in Scilit:
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