Transplantations of Newborn CNS Fragments into the Brain of Shiverer Mutant Mice: Extensive Myelination by Transplanted Oligodendrocytes
- 1 January 1986
- journal article
- research article
- Published by S. Karger AG in Developmental Neuroscience
- Vol. 8 (4), 197-207
- https://doi.org/10.1159/000112253
Abstract
As already demonstrated by immunohistochemistry, oligodendrocytes from newborn normal mice are able to survive, migrate and myelinate when transplanted into the newborn shiverer (shi/shi) mouse brain. The survival of the grafted cells and their interaction with the host brain were studied at different times after transplantation. Normal myelin was found in the host parenchyma basing our observation on the morphological difference between normal and shiverer myelin: the shiverer myelin deprived of major dense line appears uncompacted as compared to normal myelin. Myelin formed by transplanted oligodendrocytes was detected around the graft and, after immunohistochemical prelocalization, at considerable distance from the site of implantation. Normal and shiverer myelin were detected around axons adjacent to each other or around the same axon. These results confirm and extend at the ultrastructural level our previous data obtained by immunohistochemistry.This publication has 6 references indexed in Scilit:
- Cultures of shiverer mutant cerebellum injected with normal oligodendrocytes make both normal and shiverer myelin.Proceedings of the National Academy of Sciences, 1984
- Myelination ofjp,jpmsd andqk axons by normal glia in vitro: Ultrastructural and autoradiographic evidenceBrain Research, 1983
- Survival and differentiation of oligodendrocytes from neural tissue transplanted into new-born mouse brainNeuroscience Letters, 1983
- Hypomyelinated mutant mice. II. Myelination in vitroBrain Research, 1980
- Immunochemical studies of myelin basic protein in shiverer mouse devoid of major dense line of myelinNeuroscience Letters, 1979
- Absence of the major dense line in myelin of the mutant mouse ‘shiverer’Neuroscience Letters, 1979