CHANGES IN OSMOLARITY IN THE CEREBRAL VENTRICLES AND DIURESIS*

Abstract

In dogs under light anesthesia the cerebral ventricles were perfused with normotonic, hypotonic or hypertonic solutions. Several hours after the beginning of the experiments pronounced influences on urine flow were observed in those animals which showed a good kidney function. Perfusion of the cerebral ventricles with a hypotonic solution produced after about 20 minutes a marked increase in urine flow. Mean increases in diuresis of 351%, 555% and 378% were observed. Returning to a perfusion with an iso- or hypertonic solution diuresis again decreased.