Serotonin receptor binding affinities of several hallucinogenic phenylalkylamine and N,N-dimethyltryptamine analogs

Abstract

Hallucinogenic phenylalkylamine and N,N-dimethyltryptamine analogs affect serotonergic systems both in vivo and in vitro. Using a rat stomach fundus model, the 5-HT [5-hydroxytryptamine] receptor binding affinities of several of these analogs were determined and compared. The most behaviorally potent analogs examined, DOB, DOM and 5-methoxy-N,N-dimethyltryptamine, possessed rather high affinities (pA2 = 7.35, 7.12 and 7.08, respectively) for the 5-HT receptors of the model system.