The Crabtree Effect and its Relation to the Petite Mutation

Abstract

Some yeast strains are able to give rise to "petite" mutants upon treatment with euflavine while some other strains do not give rise to cytoplasmic respiration-deficient mutants. Nevertheless euflavine mimics the effect of the petite mutation in those strains which are unable to give petite mutants. There is a correlation between the presence of the Crabtree effect in a yeast strain and its ability to give petite mutants.