Transcription of the chicken histone H5 gene is mediated by distinct tissue-specific elements within the promoter and the 3' enhancer.
Open Access
- 1 May 1989
- journal article
- research article
- Published by Taylor & Francis in Molecular and Cellular Biology
- Vol. 9 (5), 2228-2232
- https://doi.org/10.1128/mcb.9.5.2228
Abstract
Molecular genetic analysis of a number of vertebrate erythroid cell-specific genes has identified at least two types of cis-acting regulatory sequences which control the complex developmental pattern of gene expression during erythroid cell maturation. Tissue-specific cellular enhancers have been identified 3' to three erythroid cell-specific genes, and additional regulatory elements have been identified in the promoters of many erythroid genes. We show that the histone H5 enhancer, like the adult beta-globin enhancer, is involved in mediating the developmental induction of histone H5 mRNA as erythroid cells mature. We also describe the preliminary characterization of a tissue-specific regulatory element within the 5' region of the H5 locus and describe investigations of the interaction between this element and the histone H5 enhancer in mediating histone H5 regulation.This publication has 35 references indexed in Scilit:
- Developmental regulation of β-globin gene switchingCell, 1988
- Erythroid-specific transcription of the chicken histone H5 gene is directed by a 3′ enhancerNature, 1987
- Cell-type specificity of iminunoglobulin gene expression is regulated by at least three DNA sequence elementsCell, 1985
- Genomic organization of the genes coding for the six main histones of the chicken: Complete sequence of the H5 geneJournal of Molecular Biology, 1983
- Hormone-dependent terminal differentiation in vitro of chicken erythroleukemia cells transformed by ts mutants of avian erythroblastosis virusCell, 1982
- Erythroblast cell lines transformed by a temperature-sensitive mutant of avian erythroblastosis virus: A model system to study erythroid differentiation in vitroJournal of Cellular Physiology, 1982
- Histone H5 messenger RNA is polyadenylatedNature, 1980
- Temperature-sensitive mutant of avian erythroblastosis virus suggests a block of differentiation as mechanism of leukaemogenesisNature, 1978
- Ribonucleic acid isolated by cesium chloride centrifugationBiochemistry, 1974
- Quantitative differences in the content of the histone f2c between chicken erythrocytes and erythroblastsExperimental Cell Research, 1972