Polyinosinic Acid ⋅ Polycytidylic Acid: Inhibition of DNA Synthesis Stimulated by Isoproterenol
- 6 March 1970
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 167 (3923), 1379-1380
- https://doi.org/10.1126/science.167.3923.1379
Abstract
Polyinosinic acid • polycytidylic acid (poly I • poly C) inhibits isoproterenol-stimulated DNA synthesis in salivary glands of mice. A single intraperitoneal injection of 250 micrograms of poly I • poly C inhibits the stimulation of DNA synthesis when given 10 minutes before isoproterenol or at any time during the 20-hour lag period between the injection of isoproterenol and the subsequent DNA synthesis. The inhibition caused by poly I • poly C is not due to a generalized toxic action but seems to be exerted through a relatively selective mechanism. Polyuridylic acid and diethylaminoethyl dextran are less effective in inhibiting isoproterenol-stimulated DNA synthesis.Keywords
This publication has 8 references indexed in Scilit:
- Toxic Properties of a Synthetic Double-stranded RNA: Embryotoxic Effect of Poly I.Poly CNature, 1969
- Toxic Properties of a Synthetic Double-stranded RNA: Pyrogenicity of Poly I.Poly C in RabbitsNature, 1969
- Toxic Properties of a Synthetic Double-stranded RNA: Endotoxin-like Properties of Poly I.Poly C, an Interferon StimulatorNature, 1969
- Stimulation of DNA synthesis by isoproterenol and its inhibition by actinomycin DExperimental Cell Research, 1967
- Secretion and Synthesis of Amylase in the Rat Parotid Gland after IsoprenalineNature, 1966
- Inhibition of stimulation of DNA synthesis by isoproterenol in submandibular glands of miceLife Sciences, 1966
- STUDIES IN HISTOCHEMISTRY: I. DETERMINATION OF NUCLEIC ACIDS IN MICROGRAM AMOUNTS OF TISSUEJournal of Histochemistry & Cytochemistry, 1956
- [17] Amylases, α and βMethods in Enzymology, 1955