The synaptic vesicle cycle: a cascade of protein–protein interactions
- 1 June 1995
- journal article
- review article
- Published by Springer Nature in Nature
- Vol. 375 (6533), 645-653
- https://doi.org/10.1038/375645a0
Abstract
The synaptic vesicle cycle at the nerve terminal consists of vesicle exocytosis with neurotransmitter release, endocytosis of empty vesicles, and regeneration of fresh vesicles. Of all cellular transport pathways, the synaptic vesicle cycle is the fastest and the most tightly regulated. A convergence of results now allows formulation of molecular models for key steps of the cycle. These developments may form the basis for a mechanistic understanding of higher neural function.Keywords
This publication has 118 references indexed in Scilit:
- Essential functions of synapsins I and II in synaptic vesicle regulationNature, 1995
- The Appendage Domain of α-Adaptin Is a High Affinity Binding Site for DynaminJournal of Biological Chemistry, 1995
- Estimates for the pool size of releasable quanta at a single central synapse and for the time required to refill the pool.Proceedings of the National Academy of Sciences, 1995
- Mechanisms of intracellular protein transportNature, 1994
- Calcium dependence of the rate of exocytosis in a synaptic terminalNature, 1994
- Synaptotagmin I is a high affinity receptor for clathrin AP-2: Implications for membrane recyclingCell, 1994
- Inhibition of endocytosis by elevated internal calcium in a synaptic terminalNature, 1994
- SNAP receptors implicated in vesicle targeting and fusionNature, 1993
- Kinesin-related gene unc-104 is required for axonal transport of synaptic vesicles in C. elegansCell, 1991
- SNAPs, a family of NSF attachment proteins involved in intracellular membrane fusion in animals and yeastCell, 1990