Stability of an expanded trinucleotide repeat in the androgen receptor gene in transgenic mice
- 1 February 1995
- journal article
- research article
- Published by Springer Nature in Nature Genetics
- Vol. 9 (2), 191-196
- https://doi.org/10.1038/ng0295-191
Abstract
The expansion of trinucleotide repeat sequences underlies a number of hereditary neurological disorders. To study the stability of a trinucleotide repeat and to develop an animal model of one of these disorders, spinal and bulbar muscular atrophy (SBMA), we have generated transgenic mice carrying either the normal or expanded repeat human androgen receptor (AR) gene. Unlike the disease allele in humans, the AR cDNA containing the expanded repeat in transgenic mice showed no change in repeat length with transmission. Expression of the SBMA AR was found in transgenic mice, but at a lower level than normal endogenous expression. The lack of a physiological pattern of expression may explain why no phenotypic effects of the transgene were observed.This publication has 27 references indexed in Scilit:
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