Reappearance of beta-adrenergic receptors after isoproterenol treatment in intact C6-cells.
Open Access
- 1 November 1983
- journal article
- research article
- Published by Rockefeller University Press in The Journal of cell biology
- Vol. 97 (5), 1538-1543
- https://doi.org/10.1083/jcb.97.5.1538
Abstract
The reappearance of beta-adrenergic receptors in C6-glioma cells after desensitization with isoproterenol was studied using the antagonist [3H]CGP-12177. Reappearance had the following properties: (a) it occurred in intact cells only, (b) it was temperature dependent, (c) it required an Na+/H+ gradient, low intracellular Ca2+ activity, and (d) it required ATP, and (e) intact lysosomes. The results suggest endocytosis and recycling of the beta-adrenergic receptor after agonist treatment.This publication has 31 references indexed in Scilit:
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