The excretion of uric acid by the kidney
- 1 September 1926
- journal article
- research article
- Published by The Royal Society in Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character
- Vol. 100 (703), 336-359
- https://doi.org/10.1098/rspb.1926.0053
Abstract
Injected uric acid is excreted by the isolated perfused kidney. The concentration of uric acid in urine is dependent upon the concentration of uric acid in the blood and also upon rate of urine flow. Uric acid both in the isolated kidney and in the intact animal has a more or less pronounced diuretic effect. Uric acid is actually secreted by tubular cells of the kidney. In the intact animal it is mainly oxidized rather than excreted, the former occurring to a far greater extent than the latter. This is also true for the heart-lung-liver-kidney preparation. The oxidation pf uric acid takes place in the liver, the product being allantoin.This publication has 8 references indexed in Scilit:
- Hydrolysis of phosphoric esters by the kidney in vivoProceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character, 1925
- The secretion of urine as studied on the isolated kidneyProceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character, 1925
- On some conditions affecting the perfusion of isolated mammalian organsThe Journal of Physiology, 1924
- AGE OF SHAD ESTIMATED FROM EXAMINATION OF SCALESScience, 1924
- THE SECRETORY FUNCTION OF THE RENAL TUBULESAmerican Journal of Physiology-Legacy Content, 1924
- THE URIC ACID PROBLEMPublished by Elsevier ,1924
- Die Wirkungen der totalen LeberexstirpationErgebnisse der Physiologie, 1924
- Untersuchungen über Physiologie und Pharmakologie des Purinhaushaltes. III. Mitteilung. Die Bestimmung des Allantoins im Harn durch Titration.Hoppe-Seyler´s Zeitschrift Für Physiologische Chemie, 1914