Interaction of Aldosterone with Liver and Kidney Cell Membranes and Subcellular Fractions of Kidney
- 1 June 1963
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 113 (2), 387-391
- https://doi.org/10.3181/00379727-113-28373
Abstract
Summary 1. A simplified method for isolation of kidney and liver cell membranes is reported. 2. Aldosterone is weakly bound to kidney subcellular fractions as demonstrated by the techniques of equilibrium fractionation and equilibrium dialysis. 3. The liver and kidney cell membranes studied were found to either take up the steroids according to their lipid solubility or to bind them in accordance with the polarity rule for steroid-protein interaction. 4. Spirolactone failed to displace aldosterone from the kidney cell membranes.Keywords
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