A Seminiferous Tubular Factor Is Not Obligatory for Regulation of Plasma Follicle-Stimulating Hormone in the Rat
- 1 March 1981
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 108 (3), 1035-1039
- https://doi.org/10.1210/endo-108-3-1035
Abstract
Plasma testosterone, FSH [follicle-stimulating hormone] and LH [luteinizing hormone] levels were measured by radioimmunoassay in sham-castrate control rats and in castrate male rats with testosterone-containing Silastic capsule implants to evaluate the relative contribution of testosterone and inhibin in maintaining normal FSH secretion in vivo. Silastic capsules maintaining normal testosterone levels maintained normal levels of both FSH and LH over the 5-day course of these studies. Testosterone or its metabolites can account for at least 78%, and possibly all, of the FSH-suppressing activity of the testis. The data do not support an obligatory role for other testicular factors, such as inhibin, in the regulation of plasma FSH when normal testosterone levels are maintained.This publication has 4 references indexed in Scilit:
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