Selection of viability at loci controlling protein polymorphisms in Drosophila melanogaster is very weak at most.
- 1 August 1980
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 77 (8), 4857-4860
- https://doi.org/10.1073/pnas.77.8.4857
Abstract
In an isolated D. melanogaster population the frequency of chromosomes carrying the 2nd chromosome inversion In(2L)t is about 60%. Three isozyme loci are nearly monomorphic in the inversion-carrying chromosomes but are highly polymorphic in other chromosomes. From known recombination frequencies and the slight polymorphism, it is estimated that the inversion-carrying chromosomes are descended from 1 or a few identical chromosomes introduced about 1000 generations previously. This is long enough for lethal and mildly deleterious mutants to reach equilibrium frequencies but not long enough for very weakly selected mutants. Because the difference in variability between homozygous and heterozygous chromosomes is the same, it is inferred that there is at most very weak selection for isozyme loci. This method is sensitive enough to detect selective differences of 0.0005 per locus or less.This publication has 15 references indexed in Scilit:
- Non-random association between electromorphs and inversion chromosomes in finite populationsGenetics Research, 1980
- THE GENETIC STRUCTURE OF NATURAL POPULATIONS OF DROSOPHILA MELANOGASTER. XIV. EFFECTS OF THE INCOMPLETE DOMINANCE OF THE IN(2LR)SM1 (Cy) CHROMOSOME ON THE ESTIMATES OF VARIOUS GENETIC PARAMETERSGenetics, 1980
- Lack of experimental evidence for frequency-dependent selection at the alcohol dehydrogenase locus in Drosophila melanogaster.Proceedings of the National Academy of Sciences, 1979
- THE GENETIC STRUCTURE OF NATURAL POPULATIONS OF DROSOPHILA MELANOGASTER XIII. FURTHER STUDIES ON LINKAGE DISEQUILIBRIUMGenetics, 1977
- A model of mutation appropriate to estimate the number of electrophoretically detectable alleles in a finite populationGenetics Research, 1973
- Genetic variability maintained in a finite population due to mutational production of neutral and nearly neutral isoallelesGenetics Research, 1968
- Evolutionary Rate at the Molecular LevelNature, 1968
- A MOLECULAR APPROACH TO THE STUDY OF GENIC HETEROZYGOSITY IN NATURAL POPULATIONS. II. AMOUNT OF VARIATION AND DEGREE OF HETEROZYGOSITY IN NATURAL POPULATIONS OF DROSOPHILA PSEUDOOBSCURAGenetics, 1966