Studies on cinoxacin

Abstract

Bacteria were isolated from urine specimens obtained from patients with chronic urinary tract diseases treated with various antibiotics and chemotherapeutics for long periods of time because of recurrent or relapsing urinary tract infections. The micro-organisms were studied for their in vitro susceptibility to cinoxacin and nalidixic acid. The Gram-negative bacteria investigated were usually more susceptible to cinoxacin than to nalidixic acid. Ninety-eight of 108 strains of Escherichia coli were inhibited by 32 μg/ml of cinoxacin and 61 by 32 μg/ml of nalidixic acid. The corresponding numbers for 27 strains of Klebsiella pneumoniae were 22 and 12, and for 25 strains of Proteus mirabilis 20 and 10, respectively. None of 16 strains of Pseudomonas aeruginosa were inhibited by cinoxacin in this concentration, nor were 24 strains of staphylococci and streptococci.