Structure of mutagen nucleic acid complexes in solution. Proton chemical shifts in 9-aminoacridine complexes with dG-dC, dC-dG, and dA-dT-dG-dC-dA-dT
- 11 July 1978
- journal article
- research article
- Published by American Chemical Society (ACS) in Biochemistry
- Vol. 17 (14), 2915-2919
- https://doi.org/10.1021/bi00607a033
Abstract
The influence of self-complementary oligodeoxynucleotides on the chemical shifts of protons of the mutagenic acridine dye 9-aminoacridine was measured. Upfield shifts indicative of intercalative binding are found in the cases of dG-dC, dC-dG and dA-dT-dG-dC-dA-dT but not in dA-dT. Geometries for the complexes that are compatible with the chemical-shift data and the X-ray structure of the complex between ri5C-rG and 9-aminoacridine determined by Sakore et al. can be identified using recent theoretical estimates of shifts induced by nucleotide bases.This publication has 7 references indexed in Scilit:
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