CIRCADIAN-RHYTHMS IN CUTANEOUS REACTIVITY TO HISTAMINE AND SELECTED ANTIGENS, INCLUDING PHASE RELATIONSHIP TO URINARY CORTISOL EXCRETION

Abstract

Intradermal skin reactions to histamine, house dust and grass pollen extracts follow a prominent circadian pattern. The response elevated in the afternoon, peaked in the evening, and had a morning trough. Urinary hydrocortisone excretion curves exhibit agreement in anti-phase timing.