The influence of maternal protein deprivation on the developmental pattern of serum immunoreactive insulin‐like growth factor 1 (IGF‐1) levels
- 1 March 1986
- journal article
- Published by Wiley in Acta Physiologica Scandinavica
- Vol. 126 (3), 391-395
- https://doi.org/10.1111/j.1748-1716.1986.tb07832.x
Abstract
The influence of maternal protein deprivation on body and brain growth and on serum immunoreactive insulin‐like growth factor 1 (IGF‐1) levels was examined in rats during development. The offspring of protein‐deprived mothers were significantly growth‐retarded postnatally and showed an altered developmental pattern of serum immunoreactive IGF‐1 levels. In contrast to control animals, between days 5 and 20 postnatally, a significant elevation in serum immunoreactive IGF‐1 levels which peaked at day 15 was found. However, in adult growth‐retarded rats a significant reduction in serum immunoreactive IGF‐1 levels was found. These findings suggested the preweaning period to be critical for the development of the mature somatomedin system.Keywords
This publication has 24 references indexed in Scilit:
- The characterization of somatomedin A, isolated by microcomputer-controlled chromatography, reveals an apparent identity to insulin-like growth factor 1European Journal of Biochemistry, 1984
- Muscle changes in protein-deprived young ratsJournal of the Neurological Sciences, 1983
- Plasma somatomedin-C in fasted and refed rats: close relationship with changes in liver somatogenic but not lactogenic binding sitesJournal of Endocrinology, 1983
- Developmental patterns of insulin-like growth factor-I and -II synthesis and regulation in rat fibroblastsNature, 1983
- Dietary components that regulate serum somatomedin-C concentrations in humans.Journal of Clinical Investigation, 1983
- Growth and SomatomedinsPublished by Elsevier ,1983
- Growth hormone receptors in rat liver membranes: Effects of fasting and refeeding, and correlation with plasma somatomedin activityMolecular and Cellular Endocrinology, 1982
- Developmental Pattern of a Serum Binding Protein for Multiplication Stimulating Activity in the RatJournal of Clinical Investigation, 1982
- Motor nerve conduction velocity and nerve fibre diameter in experimental protein deprivationActa Neuropathologica, 1980
- Barriers and transport properties of the perineuriumActa Neuropathologica, 1979