PHOSPHORUS ABSORPTION IN THE ANESTHETIZED DOG AS DETERMINED WITH THE RADIOACTIVE ISOTOPE

Abstract

A study was made of the distribution of radioactive P, introduced directly into the duodenum of the dog, during the 4 hrs. immediately following the adm. of the isotope. Labeled P appeared in the general circulation within 5 mins. The maximum change in the P+ content of the portal and jugular blood occurred within the 1st 1/2 hr.; the portal P+ level exceeded that of the jugular and carotid blood significantly for 3-3 1/2 hrs. The specific activity of the liver rose rapidly for 2 1/2 hrs., after which it remained fairly constant. At the end of 4 hrs., between 0.4 and 5% of the dose could be washed out of the small intestine and the intestinal tissue contained 20% of the dose[long dash]9/10 of which was in the mucosa.