Factor required for mammalian spliceosome assembly is localized to discrete regions in the nucleus
- 1 February 1990
- journal article
- Published by Springer Nature in Nature
- Vol. 343 (6257), 437-441
- https://doi.org/10.1038/343437a0
Abstract
A monoclonal antibody raised against mammalian spliceosomes specifically recognizes a non-snRNP factor required for spliceosome assembly. This splicing factor is highly concentrated in discrete regions within the nucleus, in a pattern that is a distinct subset of that seen with anti-snRNP antibodies. These observations are evidence that spliceosome assembly could be compartmentalized within the nucleus.Keywords
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