Prevention and management of bicalutamide-induced gynecomastia and breast pain: randomized endocrinologic and clinical studies with tamoxifen and anastrozole
- 1 February 2005
- journal article
- clinical trial
- Published by Springer Nature in Prostate Cancer and Prostatic Diseases
- Vol. 8 (1), 75-83
- https://doi.org/10.1038/sj.pcan.4500782
Abstract
A randomized, double-blind, placebo-controlled multicenter trial involving 107 men receiving bicalutamide ('Casodex') 150 mg/day therapy following radical therapy for prostate cancer assessed tamoxifen ('Nolvadex') 20 mg/day and anastrozole ('Arimidex') 1 mg/day for the prophylaxis and treatment of gynecomastia/breast pain. Tamoxifen, but not anastrozole, significantly reduced the incidence of gynecomastia/breast pain when used prophylactically and therapeutically. Serum testosterone levels increased with tamoxifen relative to placebo but prostate-specific antigen levels declined in all treatment groups. Further studies are needed to define the optimum tamoxifen dose and to assess any impact on cancer control. The use of tamoxifen in this setting remains to be investigated.Keywords
This publication has 14 references indexed in Scilit:
- BICALUTAMIDE 150 MG IN ADDITION TO STANDARD CARE IN PATIENTS WITH LOCALIZED OR LOCALLY ADVANCED PROSTATE CANCER: RESULTS FROM THE SECOND ANALYSIS OF THE EARLY PROSTATE CANCER PROGRAM AT MEDIAN FOLLOWUP OF 5.4 YEARSJournal of Urology, 2004
- Prophylactic breast irradiation with a single dose of electron beam radiotherapy (10 Gy) significantly reduces the incidence of bicalutamide-induced gynecomastiaInternational Journal of Radiation Oncology*Biology*Physics, 2004
- Does prophylactic breast irradiation prevent antiandrogen-induced gynecomastia? Evaluation of 253 patients in the randomized Scandinavian trial SPCG-7/SFUO-3Urology, 2003
- Gynecomastia in patients with prostate cancer: a review of treatment optionsUrology, 2000
- BICALUTAMIDE MONOTHERAPY COMPARED WITH CASTRATION IN PATIENTS WITH NONMETASTATIC LOCALLY ADVANCED PROSTATE CANCER: 6.3 YEARS OF FOLLOWUPJournal of Urology, 2000
- Aromatase and gynecomastia.Endocrine-Related Cancer, 1999
- Tamoxifen for flutamide/finasteride-induced gynecomastiaUrology, 1997
- Endocrine profiles during administration of the new non‐steroidal anti‐androgen Casodex in prostate cancerClinical Endocrinology, 1994
- Tamoxifen Therapy for Painful Idiopathic GynecomastiaSouthern Medical Journal, 1990
- Treatment of gynecomastia with tamoxifen: A double-blind crossover studyMetabolism, 1986