Histopathology of remodelling induced by PUVA in the superficial dermis

Abstract
The histopathological alterations induced by PUVA within the skin are reported in a patient treated for psoriasis. The main impact is located at the site of former psoriatic plaques in which the target is the microvasculature. A residual coating sheath is present around vessels and fibrosis appears in the superficial dermis. These remodellings interfere with the normal dermo—epidermal relationships; the epidermis contains atypical keratinocytes, and melanocytes are no longer recognizable.