Molecular biology of duchenne and Becker's muscular dystrophy: Clinical applications
- 1 August 1989
- journal article
- review article
- Published by Wiley in Annals of Neurology
- Vol. 26 (2), 189-194
- https://doi.org/10.1002/ana.410260202
Abstract
Recent advances in molecular genetics have led to the isolation of the gene defective in patients with Duchenne and Becker's muscular dystrophy and the characterization of its protein product, dystrophin. In this communication, the developments culminating in the identification of the Duchenne muscular dystrophy locus are reviewed. The practical applications of this research and pitfalls that limit prenatal diagnosis and carrier detection are discussed.Keywords
This publication has 43 references indexed in Scilit:
- Mosaic Expression of Dystrophin in Symptomatic Carriers of Duchenne's Muscular DystrophyNew England Journal of Medicine, 1989
- Characterization of Dystrophin in Muscle-Biopsy Specimens from Patients with Duchenne's or Becker's Muscular DystrophyNew England Journal of Medicine, 1988
- INHERITED DELETION AT DUCHENNE DYSTROPHY LOCUS IN NORMAL MALEThe Lancet, 1987
- A partial deletion of the muscular dystrophy gene transmitted twice by an unaffected maleNature, 1987
- Germline mosaicism and Duchenne muscular dystrophy mutationsNature, 1987
- Complete cloning of the duchenne muscular dystrophy (DMD) cDNA and preliminary genomic organization of the DMD gene in normal and affected individualsCell, 1987
- Prenatal Diagnosis and Detection of Carriers with DNA Probes in Duchenne's Muscular DystrophyNew England Journal of Medicine, 1987
- RECOMBINATION WITH PERT87 (DXS164) IN FAMILIES WITH X-LINKED MUSCULAR DYSTROPHYThe Lancet, 1986
- Duchenne‐like muscular dystrophy in two sisters with normal karyotypes: evidence for autosomal recessive inheritanceClinical Genetics, 1985
- Severe Autosomal Recessive Muscular Dystrophy in an Extended Sudanese KindredDevelopmental Medicine and Child Neurology, 1983