The gender effect in stroke thrombolysis
- 30 September 2008
- journal article
- research article
- Published by Wolters Kluwer Health in Neurology
- Vol. 71 (14), 1080-1083
- https://doi.org/10.1212/01.wnl.0000316191.84334.bd
Abstract
Background: Large studies of patients with acute stroke not receiving thrombolytic therapy have repeatedly demonstrated poorer outcomes for women compared to men. An analysis of five pooled randomized controlled trials testing IV recombinant tissue plasminogen activator (rtPA) demonstrated that rtPA benefits women more than men; the usual gender difference, apparent among controls, was totally nullified in the rtPA group. This nullification of the usual gender effect among rtPA-treated patients has not been confirmed.Keywords
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