Cysteinyl leukotriene receptor CysLT1as a novel therapeutic target for allergic rhinitis treatment
- 18 March 2008
- journal article
- review article
- Published by Informa Healthcare in Emerging Therapeutic Targets
- Vol. 12 (4), 415-423
- https://doi.org/10.1517/14728222.12.4.415
Abstract
Background: Cysteinyl leukotrienes (cys-LTs) play an important role in allergic rhinitis because CysLT1 receptor antagonists relieve the symptoms of allergic rhinitis. Objective: I overview the clinical pharmacology of CysLT1 receptor antagonists and their potential role in patients with allergic rhinitis. Methods: I review the evidence regarding the release of cys-LTs and localization of CysLT1 receptor on nasal mucosa, and evaluate the clinical efficacy of CysLT1 receptor antagonist in allergic rhinitis. Results/conclusion: Immunohistochemical studies show that in allergic rhinitis, the major target of CysLT1 receptor antagonists are the vascular bed and infiltrated leukocytes such as mast cells, eosinophils and macrophages. CysLT1 receptor antagonists provide a new opportunity for simultaneous management of allergic diseases of the upper and lower respiratory tract.Keywords
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