Inhibition of nitric oxide synthesis enhances leukocyte rolling and adhesion in human microvasculature
Open Access
- 19 July 2012
- journal article
- Published by Springer Nature in Journal of Inflammation
- Vol. 9 (1), 28
- https://doi.org/10.1186/1476-9255-9-28
Abstract
Nitric oxide (NO) is a multifunctional signaling molecule that regulates important cellular events in inflammation including leukocyte recruitment. Previous studies have shown that pharmacological inhibition of NO synthesis induces leukocyte recruitment in various in vitro and animal models. However, it is not known whether NO modulation has similar effects on leukocyte-endothelial cell interactions within the human microvasculature. The present study explored the effect of systemic L-NAME treatment on leukocyte recruitment in the SCID-hu mouse model.Keywords
This publication has 55 references indexed in Scilit:
- P-selectin mediates neutrophil rolling and recruitment in acute pancreatitisBritish Journal of Surgery, 2012
- Leukocyte – endothelial interactions in inflammationJournal of Cellular and Molecular Medicine, 2009
- Neutrophil Adhesion and Activation under FlowMicrocirculation, 2009
- A novel hybrid aspirin-NO-releasing compound inhibits TNFalpha release from LPS-activated human monocytes and macrophagesJournal of Inflammation, 2008
- Nitric Oxide Regulates Neutrophil Migration through Microparticle FormationThe American Journal of Pathology, 2008
- CXC-chemokine regulation and neutrophil trafficking in hepatic ischemia-reperfusion injury in P-selectin/ICAM-1 deficient miceJournal of Inflammation, 2007
- l-NAME–induced neutrophil accumulation in rat lung is not entirely because of interactions with L- and P-selectins or CD18Journal of Pediatric Surgery, 2006
- L-NAME Induces Direct Arteriolar Leukocyte Adhesion, Which Is Mainly Mediated by Angiotensin-IIMicrocirculation, 2005
- Nitric oxide regulates interactions of PMN with human brain microvessel endothelial cellsBiochemical and Biophysical Research Communications, 2004
- Hepatocyte growth factor/scatter factor suppresses TNF-α-induced E-selectin expression in human umbilical vein endothelial cellsBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2004