Aging Increases Susceptibility of Mouse Skin to DMBA Carcinogenesis Independent of General Immune Status
- 18 January 1974
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 183 (4121), 217-218
- https://doi.org/10.1126/science.183.4121.217
Abstract
The dependence of chemical carcinogenesis on age of target tissue was studied by repeated DMBA-treatment of mouse skin grafted from old and young syngeneic donors to young recipients. Carcinomas developed on 39 percent (1.6/41) of grafts from old donors and on 12 percent (5/41) of grafts from young donors. The incidence of nonskin lymphoid tumors was highest in male recipients bearing grafts from old donors.Keywords
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