THE EFFECTS OF CERTAIN PURINES AND PYRIMIDINES UPON THE PRODUCTION OF RIBOFLAVIN BY EREMOTHECIUM ASHBYII

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Abstract
Xanthine, adenine, guanine, uric acid and possibly hypoxanthine were effective in promoting riboflavin production in a manner independent of the growth of E. ashbyii. Xanthins increased the production of riboflavin as much as 39%. An hypothesis is presented to account for the action of certain purines as precursors in the formation of riboflavin by E. ashbyii which points to the possible existence of a "purine pathway" in the process of riboflavin biosynthesis. Uracil was found to inhibit the production of riboflavin to a marked extent, with a maximum effect of 83%.