An unidentified lipid prevalent in tumors
- 1 November 1966
- Vol. 1 (6), 381-386
- https://doi.org/10.1007/bf02532540
Abstract
An unidentified lipid was found in five different tumor sources. It was not found in liver, bone marrow or plasma from tumor-bearing animals, nor in the extracellular fluid supporting growth of Ehrlich ascites cells. The polarity of the unidentified component was similar to that of a glyceryl ether diester, and it was isolated in milligram amounts by preparative thinlayer chromatography. Neither methyl esters of fatty acids, vinyl ether diesters nor quinones were found in the structural makeup of this lipid. Thin-layer chromatography of the purified unidentified tumor lipid on Ag-impregnated silica layers revealed two main components of intermediary unsaturation. Saponification of the unidentified tumor lipid, when water washing was omitted, yielded two components that migrated at Rf's identical to those of free fatty acids and dihydroxy glyceryl monoethers. Neither acetate-1-14C nor palmitic-1-14C acid (single injections) was found to be incorporated into the unidentified lipid of a mature rat tumor.This publication has 20 references indexed in Scilit:
- Alkoxylipids. II. “Neutral plasmalogens” in the liver oil of the ratfish (Hydrolagus colliei)Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1966
- An automtic zonal scraper and sample collector for radioassay of thin-layer chromatogramsAnalytical Biochemistry, 1965
- Thin-layer chromatography of naturally occurring quinones and hydroquinonesAnalytical Biochemistry, 1964
- The incorporation of [14C]formate into ehrlich ascites tumor lipidsBiochimica et Biophysica Acta, 1963
- Malignolipin and Malignant TumoursNature, 1962
- Metabolism and functions of phosphatidesZeitschrift für Krebsforschung und Klinische Onkologie, 1960
- Reaction of Mercuric Chloride with PlasmalogenNature, 1959
- MalignolipinScience, 1958
- A New Phospholipid, Malignolipin, in Human Malignant TumorsScience, 1958