Molecular Cloning and Disease Association of Hepatitis G Virus: A Transfusion-Transmissible Agent
- 26 January 1996
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 271 (5248), 505-508
- https://doi.org/10.1126/science.271.5248.505
Abstract
An RNA virus, designated hepatitis G virus (HGV), was identified from the plasma of a patient with chronic hepatitis. Extension from an immunoreactive complementary DNA clone yielded the entire genome (9392 nucleotides) encoding a polyprotein of 2873 amino acids. The virus is closely related to GB virus C (GBV-C) and distantly related to hepatitis C virus, GBV-A, and GBV-B. HGV was associated with acute and chronic hepatitis. Persistent viremia was detected for up to 9 years in patients with hepatitis. The virus is transfusion-transmissible. It has a global distribution and is present within the volunteer blood donor population in the United States.Keywords
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