Prostacyclin (PGI2) decreases the cyclic AMP level in coronary arteries

Abstract

The effects of prostacyclin (PGI₂) on vascular tension and cAMP content were measured in isolated bovine coronary artery strips. 3 nM PGI₂ did not alter the tension but diminished the cAMP content by 56% of the control level (P2 diminished the tension and further reduced the cAMP content, which amounted to only 5% of the control at 300 nM PGI₂. These results are in contrast to the increase in cAMP level by PGI₂ in blood platelets and might indicate a different mechanism of action of PGI₂ in platelets and vascular tissue.