LACTIC ACID FORMATION IN MEDULLATED NERVE

Abstract

Resting frog nerve contains about 33 mgm. % lactic acid. Lactic acid formation in H2 and in CO containing 6% O2 corresponds to about 20 mgm. % per hr. Lactic acid which has accumulated in H2 or in CO may be partially removed in O2, the rate of removal averaging about 6 mgm. % per hr. Stimulation in CO containing 6% O2 causes no excess lactic acid formation, the nerves remaining irritable for hours under these conditions.