Late results of treatment of sleeping sickness in Sierra Leone by antrypol tryparsamide pentamidine and propamidine singly and in various combinations

Abstract

A detailed survey in Sierra Leone of over 2000 sleeping sickness cases that had been treated with various drugs indicated that a combination of antrypol and tryparsamide is highly successful. Following antrypol or pentamidine treatments patients have a prolonged protection against reinfection. A short course of treatments with pentamidine and t ryparsamide seemed promising and is worthy of further trials, especially in cases resistant to tryparsamide alone. Case histories were followed for an average of 17 months each before a final decision as to the success or failure of any particular treatment was made.