Multiplicity of germline genes specifying a group of related mouse κ chains with implications for the generation of immunoglobulin diversity
- 1 December 1978
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 276 (5690), 780-784
- https://doi.org/10.1038/276780a0
Abstract
The number of germline genes specifying the variable sequences of V.kappa.21 group of L chains was determined by saturation hybridization analysis to be 4-6. This gene multiplicyt is considerably less than the total variability in the group, indicating that .kappa.-chain diversity is generated by somatic mutations in both framework and complementarity-determining (hypervariable) regions.This publication has 26 references indexed in Scilit:
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