HPLC, MS, and Pharmacokinetics of Melphalan, Bisantrene and 13-cis Retinoic Acid
- 1 November 1982
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Chromatographic Science
- Vol. 20 (11), 511-516
- https://doi.org/10.1093/chromsci/20.11.511
Abstract
High performance liquid chromatographic procedures are described for melphalan, bisantrene, and 13-cis retinoic acid, three important anticancer drugs in various stages of clinical development. The procedures require a rapid and simple sample clean-up followed by a 10-to 20-min chromatographic separation on a reversed-phase C18 column. Precisions are all less than 8% with recoveries greater than 80%. Mass spectrometry confirmation of each drug from patient sample separations is presented to provide unambiguous identification for valid pharmacokinetic parameter determination.This publication has 8 references indexed in Scilit:
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