Pemphigus controlled by dapsone

Abstract

Three uncomplicated [human] cases of pemphigus were clinically controlled by dapsone. Improvement was associated with decreasing titers of circulating intercellular antibodies. The sera from 1 case of pemphigus foliaceus contained intercellular antibodies found in the Malpighian and basal cell layers using the fluorescent technique and in the granular layer using the peroxidase technique. The intercellular antibodies in pemphigus vulgaris and pemphigus foliaceus are apparently similar but bind at different anatomical sites.