New approaches to the treatment of congenital adrenal hyperplasia.
- 2 April 1997
- journal article
- case report
- Published by American Medical Association (AMA) in JAMA
- Vol. 277 (13), 1073-1076
- https://doi.org/10.1001/jama.1997.03540370063038
Abstract
SELECTED CASE A female patient, now 7 years 6 months old, had developed pubic hair at approximately 2 years of age. At 4 years of age she developed acne and was taken to a pediatrician. Findings on physical examination included a height of 109 cm (95th percentile), a weight of 17 kg (75th percentile), Tanner I breasts, Tanner II pubic hair, clitoromegaly (clitoral index of 49 mm2; normal,12), posterior labial fusion, and acne. The bone age was advanced (6 years 10 months). Serum levels were as follows: 17-hydroxyprogesterone, 380 nmol/L (normal, <2.7 nmol/L); androstenedione, 11.2 nmol/L (normal, <1.7 nmol/L); testosterone, 1.4 nmol/L (0.40 ng/mL) (normal, <1.0 nmol/L [<0.29 ng/mL]); dehydroepiandrosterone, 7.6 nmol/L (normal, 0.6-2.1 nmol/L); and upright renin, 2.9 μg/L per hour (normal, 0.1-6.5 μg/L per hour). She was diagnosed as having congenital adrenal hyperplasia (CAH) caused by 21-hydroxylase deficiency and began treatment with hydrocortisoneKeywords
This publication has 6 references indexed in Scilit:
- A constitutively activating mutation of the luteinizing hormone receptor in familial male precocious pubertyNature, 1993
- Fatal and Nonfatal Hepatotoxicity Associated with FlutamideAnnals of Internal Medicine, 1993
- The clitoral index: A determination of clitoral size in normal girls and in girls with abnormal sexual developmentThe Journal of Pediatrics, 1992
- Congenital Adrenal Hyperplasia Due to 21-Hydroxylase DeficiencyNew England Journal of Medicine, 1990
- Cortisol production rate in childhood and adolescenceThe Journal of Pediatrics, 1990
- Anogenital ratio: Measure of fetal virilization in premature and full-term newborn infantsThe Journal of Pediatrics, 1987