Carbamazepine in the Treatment of Neuralgia

Abstract

CARBAMAZEPINE (Tegretol) has been used for more than eight years in other countries for the treatment of epilepsy and, more recently, trigeminal neuralgia. The earliest reports on its effect in trigeminal neuralgia were by Blom^1,2 in Sweden, Bonduelle et al³ in France, and Spillane⁴ and Taylor⁵ in England. Since then, there have been a number of additional papers.^6-9 The authors are in agreement on the effectiveness of this drug in trigeminal neuralgia, but the type and number of side effects have been quite variable. There have been occasional reports of serious hematopoietic effects,^10,11 but no repeated blood studies over long periods have been reported. The present study was undertaken to evaluate the side effects and also the application of this drug in some of the other neuralgias such as postherpetic, tabetic, and atypical facial neuralgia. A double-blind technique was necessary. Carbamazepine is an