Adrenergic regulation of glucagon and insulin secretion during immobilization stress in normal and spontaneously diabetic BB rats
- 31 March 1981
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Endocrinology and Metabolism
- Vol. 240 (4), E373-E378
- https://doi.org/10.1152/ajpendo.1981.240.4.e373
Abstract
To test for a possible role of adrenergic mechanisms in the altered glucagon secretion in the spontaneously diabetic "BB" rat, the responses of glucose, insulin, and glucagon to adrenergic blocking agents in diabetic and normal rats were compared at rest and during 2 h of immobilization stress. In unstressed normal rats, phentolamine alone caused a 20 mg/dl fall in glycemia, 1.2 ng/ml rise in insulin (IRI), and no change in glucagon (IRG), whereas the only effect of propranolol was a minor rise in glycemia. Stress caused increments in glycemia of 72 mg/dl and in IRG of 94 pg/ml, and no change in IRI. Phentolamine significantly attenuated the stress-related increments, and IRI increased by the same amount as in the unstressed state. Propranolol exhibited no statistically significant effects on the response to stress. These findings are consistent with alpha-adrenergic stimulation of IRG and suppression of IRI secretion. In unstressed diabetic rats (mean time 0 glycemia, 431 mg/dl), propranolol caused only a small rise in glycemia, whereas phentolamine induced marked increments of glycemia (131 mg/dl) and IRG (116 pg/ml). Stress alone did likewise (189 mg/dl, 122 pg/ml) as did stress with the phentolamine (271 mg/dl, 144 pg/ml). However propranolol significantly attenuated the stress-induced increments in glycemia (88 mg/dl) and IRG (82 pg/ml). Thus both alpha- and beta-adrenergic receptors influence IRG secretion in the diabetic rats. An in vivo model for elucidating neural control of glucoregulation has been developed that is independent of cardiovascular fitness.This publication has 23 references indexed in Scilit:
- Dopamine during α- or β-Adrenergic Blockade in ManJCI Insight, 1979
- The Metabolic Response to Hypocaloric Protein Diets in Obese ManJCI Insight, 1978
- EFFECTS OF SYMPATHETIC INNERVATION AND TEMPERATURE ON THE PROPERTIES OF RAT HEART ADRENOCEPTORSBritish Journal of Pharmacology, 1977
- Studies on the Mechanism of Epinephrine-induced Hyperglycemia in Man: Evidence for Participation of Pancreatic Glucagon SecretionDiabetes, 1976
- The Effect of Adrenergic Blockade on Exercise-Induced Hyperglucagonemia*Endocrinology, 1974
- Mechanisms Involved in the Exercise-induced Increase in Glucagon Secretion in RatsDiabetes, 1974
- Plasma Norepinephrine and Epinephrine in Untreated Diabetics, During Fasting and After Insulin AdministrationDiabetes, 1974
- Adrenergic Receptors and the Secretion of Glucagon and Insulin from the Isolated, Perfused Canine PancreasJCI Insight, 1973
- Adrenal and Urinary Catecholamines in Rats During Adaptation to Repeated Immobilization StressEndocrinology, 1970
- The effect of immobilization stress on the activity of central monoamine neuronsLife Sciences, 1968