A new benzyl ester resin with increased stability during Nα-t-butyloxycarbonyl deblocking in solid-phase peptide synthesis

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Abstract
A p-carbamoylmethylbenzyl ester linkage between Boc-phenylalanine and polystyrene resin has been prepared and shown to possess great stability toward trifluoroacetic acid and good reactivity toward liquid HF as demonstrated by the synthesis of a model peptide.