THE RENAL TUBULAR REABSORPTION OF GLUCOSE IN THE NORMAL DOG

Abstract

The tubular reabsorption of glucose has been examined by the simultaneous detn. of glucose and creatinine clearances at various arterial plasma glucose concs. in the normal dog. The essential limitation in the reabsorptive process lies in the circumstance that the tubules are able to transfer only a certain maximal quantity of glucose from the tubular urine to the blood per unit time. When the rate of glo-inorular filtration of glucose is such that glucose is delivered to the tubules at less than this maximal rate, reabsorption is essentially complete. This relationship has been discussed in relation to an hypothesis suggested to describe a similar limitation in the tubular excretion of certain substances.