In Vitro Antiviral Activity of Dammar Resin Triterpenoids

Abstract

Nine triterpenes with antiviral activity against Herpes simplex virus types I and II in vitro were isolated from dammar resin [commercially isolated from members of the Dipterocarpaceae]. Each compound caused a significant reduction in viral cytopathic effect when Vero cells were exposed continuously to 1-10 .mu.g/ml of compound for 48 h after viral challenge. The triterpenes were identified as dammaradienol [1], dammarenediol-II [2], hydroxydammarenone-I [3], ursonic acid [5], hydroxyhopanone [11], dammarenolic acid [15], shoreic acid [16], eichlerianic acid [17], and a novel compound, hydroxyoleanonic lactone [7], on the basis of their chromatographic, spectroscopic, and physical properties.