DIFFERENTIAL EFFECTS OF THE CALCIUM‐ANTAGONISTIC VASODILATORS, NIFEDIPINE AND VERAPAMIL, ON THE TRACHEAL MUSCULATURE AND VASCULATURE OF THE DOG
- 1 April 1980
- journal article
- research article
- Published by Wiley in British Journal of Pharmacology
- Vol. 68 (4), 595-597
- https://doi.org/10.1111/j.1476-5381.1980.tb10848.x
Abstract
In anaesthetized dogs the trachea in situ was perfused arterially with blood, and drugs were injected intraarterially. Isoprenaline and the calcium-antagonistic vasodilators, nifedipine and verapamil, increased tracheal blood flow and decreased resting tone of the trachea. Isoprenaline was equi-effective in producing tracheal vasodilatation and tracheal dilatation. The two calcium-antagonistic vasodilators were less effective tracheal dilators than tracheal vasodilators.Keywords
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