Enzymatic preparation of enantiomerically pure and selectively protected 1,2- and 1,3-diols

Abstract

The optically pure, selectively protected 1,2- and 1,3-diol derivatives (R)- and (S)-1–8 have been prepared by enzymatic hydrolysis of their racemic acetates and chloroacetates in the presence of ester hydrolase from Pseudomonas fluorescens(SAM-1).