Effects of Physico-Chemical State of Vit. B12 Preparation in Digestive Tract on Its Absorption.

Abstract

Two means of enhancing Vit. B₁₂ absorption in rats have been described. It was found that certain surface active agents, such as Tween 80, Tween 85 and G-1096, which form a semi-solid matter with an equal volume of water markedly enhanced absorption of Co⁶⁰B₁₂ when fed by stomach tube immediately before oral dose of Co⁶⁰B₁₂. The effect was abolished upon dilution of the agent with water before administration. Oral Vit.