Effect of various pharmacologic agents on cerebral arteries

Abstract

It was that serotonin is a potent constrictor and, as such, may play an important role in the etiology of the cerebral vasospasm that occurs following rupture of intracranial aneurysms. This constrictive effect can be both prevented and relieved by methysergide, a strong antiserotonin agent. In the intact anesthetized monkey, intracarotid infusions of histamine, papaverine, and isoxsuprine as well as inhalation of 10% CO2 had strong cerebral vasodilator properties.