22 patients with previously untreated stage I and II Hodgkin’s disease, representing all of the Lukes und Bulter histologic types, were randomized to three treatment programs. Patients in group A received radiotherapy to involved plus adjacent node-bearing areas. Patients in group B were treated with radiotherapy to involved nodal areas only and then received three courses of MOPP therapy. The patients in group C were treated with three courses of MOPP therapy, followed by radiotherapy to involved nodal areas. Four of 7 patients in group A have relapsed 3, 21, 42 and 48 months after the completion of therapy. None of the patients in group B have relapsed during a follow-up period of 33–54 months (average, 46 months). The majority of relapses have occurred in group C, with 4 of 7 patients relapsing 5, 6, 15 and 20 months after the completion of therapy. The preliminary results of this small study suggest that localized radiotherapy followed by systemic combination chemotherapy may be superior to localized radiotherapy alone for apparently localized Hodgkin’s disease. Continued follow-up of these patients, and the admission of new patients to this study may substantiate this trend.