VASOPRESSIN STIMULATION OF THE ISOLATED ADRENAL GLANDS: NATURE AND MECHANISM OF HYDROCORTISONE SECRETION12
- 1 September 1960
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 67 (3), 298-310
- https://doi.org/10.1210/endo-67-3-298
Abstract
By means of direct arterial per -fusion of the adrenal glands of the hypophysectomized dog, it has been shown that synthetic lysine, arginine and acetyl arginine vasopressins stimulate the adrenal cortex directly to secrete hydrocortisone. Maximal cortisol secretion occurred at dose ranges of 100 to 400 milliunits per minute, with minimal activity being detected with values as low as 1 milliunit per minute of arginine vasopressin. At maximal dosages the response was comparable to that seen following 1 unit per minute of ACTH. Pressor activity and cortisol stimulating activity were demonstrated to be independent to each other. In addition similar polypeptides such as oxytocin, insulin and glucagon and pressor amines such as epinephrine and norepinephrine did not show any cortisol stimulating activity. ACTH was consistently found to increase aldo-sterone secretion when perfused through the glands of hypophysectomized animals. The probable role of arginine vasopressin as a factor in the stress reaction is discussed as well as its posulated ability to activate adrenal phosphorylase.Keywords
This publication has 22 references indexed in Scilit:
- THE ACTH-RELEASING ACTIVITY OF EXTRACTS OF THE POSTERIOR LOBE OF THE PITUITARY IN VIVO1Endocrinology, 1957
- Effect of Arginine-Vasopressin and Lysine-Vasopressin on Plasma 17-Hydroxycorticosteroid Levels in ManExperimental Biology and Medicine, 1956
- Effect of Pitressin on Adrenocortical Activity in ManExperimental Biology and Medicine, 1956
- Secretion of Aldosterone by the Adrenal of the DogAmerican Journal of Physiology-Legacy Content, 1955
- Evidence for a Role of the Supraopticohypophyseal System in Regulation of Adrenocorticotropic SecretionExperimental Biology and Medicine, 1954
- THE SECRETION OF AN ANTIDIURETIC SUBSTANCE INTO THE CIRCULATION OF RATS EXPOSED TO NOXIOUS STIMULI12Endocrinology, 1954
- Decreased Resistance to Hemorrhage in Neurohypophysectomized DogsCirculation Research, 1954
- Methods of paper chromatography of steroids applicable to the study of steroids in mammalian blood and tissuesBiochemical Journal, 1952
- AN ANTIDIURETIC SUBSTANCE IN THE BLOOD OF NORMAL AND ADRENALECTOMIZED RATS1,2Endocrinology, 1950
- THE ANTIDIURETIC ACTION OF BARBITURATES (PHENOBARBITAL, AMYTAL, PENTOBARBITAL) AND THE MECHANISM INVOLVED IN THIS ACTION1945