Complications of Methysergide Therapy

Abstract

Methysergide has been implicated as a causative agent of inflammatory fibrotic processes. A positive direct Coombs' test, associated with a hemolytic anemia, was obtained from a patient who had been receiving methysergide and who also had retroperitoneal fibrosis and mitral insufficiency. It is likely that the valvular disease, retroperitoneal fibrosis, and hemolytic anemia are all part of an autoimmune process induced by methysergide.