Hepatocarcinogenicity of Glandless Cottonseeds and Cottonseed Oil to Rainbow Trout ( Salmo gairdnerii )
- 18 April 1980
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 208 (4441), 309-311
- https://doi.org/10.1126/science.6892734
Abstract
Glandless cottonseed kernels are available for purchase and consumption by the general public. These kernels contain no gossypol but still have a full complement of naturally occurring cyclopropenoid fatty acids, which in rainbow trout are active as synergists with aflatoxins and primary liver carcinogens. Diets containing glandless cottonseed kernels or a lightly processes cottonseed oil produced significant numbers of hepatocellular carcinomas in rainbow trout after 1 year. The much greater incidence of cancer induced by the kernel than by the oil indicates that synergists or other carcinogens may be present in the kernel in addition to the cyclopropenoid fatty acids.Keywords
This publication has 18 references indexed in Scilit:
- NEOPLASMS IN RAINBOW TROUT, A SENSITIVE ANIMAL MODEL FOR ENVIRONMENTAL CARCINOGENESIS*Annals of the New York Academy of Sciences, 1977
- Cholesterol levels, atherosclerosis and liver morphology in rabbits fed cyclopropenoid fatty acidsFood and Cosmetics Toxicology, 1976
- The reliability of a procedure for the determination of nitrosamines in foodFood and Cosmetics Toxicology, 1975
- Liver composition and histology of rainbow trout fed cyclopropenoid fatty acidsExperimental and Molecular Pathology, 1975
- Description of the thermal energy analyzer (TEA) for trace determination of volatile and nonvolatile N-nitroso compoundsAnalytical Chemistry, 1975
- Mitogenic Activity of Sterculic Acid, a Cyclopropenoid Fatty AcidScience, 1974
- Assay of cyclopropenoid lipids by nuclear magnetic resonanceJournal of Oil & Fat Industries, 1972
- Effects of gossypol on rainbow trout Salmo guirdneri RichardsonJournal of Fish Biology, 1970
- Prenatal and Postnatal Mortality of Offspring of Cyclopropenoid Fatty Acid-Fed RatsExperimental Biology and Medicine, 1969
- Gas‐liquid chromatographic analysis of cyclopropenoid fatty acidsJournal of Oil & Fat Industries, 1968